140 Journal of Comparative Neurology. 



which Warthin (9) has made. He has found the Pacinian cor- 

 puscles pathologically altered in a number of cases in which 

 there was present diffuse and often intense abdominal pain. Of 

 his report, attention may be drawn to two cases (VI and VII) 

 in which there was a history of abdominal pain. Ovariotomy 

 was resorted to as a means of relief With the ovaries and 

 tubes there were removed small hyalin bodies found in the mes- 

 entery. The ovaries showed only changes peculiar to the 

 menopause and no pathological conditions were found in the 

 tubes. The hyalin bodies proved to be pathologically changed 

 Pacinian corpuscles. No doubt other large and small medulla- 

 ted nerves, especially of the hypogastric nerves, terminate in 

 the peculiar, encapsulated sensory endings described by Tim- 

 ofeew (10) and found by him in the connective tissue capsule 

 and between the muscle bundles and glands of the prostate 

 gland of the dog and cat and in the membranous portion of 

 the urethra of the same animals. I have seen these endings in 

 the mucous membrane of the membranous portion of the 

 urethra in a female cat and could readily duplicate his figures. 

 Such special sensory nerve endings would not, however, account 

 tor all the larger medullated fibers, which we have regarded as 

 afferent fibers, which are found in the sympathetic system. 

 We possess, however, a number of observations which go to 

 show that medullated nerve fibers terminate in the viscera and 

 gland ducts in free sensory endings. 



Some years ago Arnstein (11) and the writer (12) described 

 free sensory endings in the larger ducts of the salivary glands. 

 Ploschko (13) has described sub-epithelial and intra-epithelial 

 sensory endings in the epiglottis, larynx and trachea. He fur- 

 ther describes relatively large medullated fibers which pass 

 through the sympathetic ganglia found in the trachea and end in 

 rather compact arborizations situated in the involuntary muscle 

 of the trachea. It was above stated that ths plexuses found in 

 involuntary muscle were formed by the division and interlace- 

 ment of the neuraxes of motor, sympathetic neurones. The 

 above apparent exception does not, it seems to me, necessitate 

 a modification of this general statement. Since the sensory 



