148 Journal of Comparative Neurology. 



as Dogiel (25) has observed, there are to be found medullated 

 nerves which do not end in the sympathetic gangha. In the 

 gall bladder, owing perhaps to the presence of the bile, or to the 

 brownish stain of the epithelium, I have not been able to make 

 out the endings of such fibers. In one methylen blue prepara- 

 tion of the bile duct of a cat, I was able to make out several 

 arborizations in the mucosa — thus above the muscular coat — 

 and from one of these some few terminal branches could be 

 traced into the epithelium. This was in a preparation before it 

 was fixed. It is of course well known that relatively large 

 medullated fibers may be traced to the stomach and intestinal 

 canal. Some of these may be traced through the ganglia of 

 Meissner's and Auerbach's plexuses, as has been shown by 

 Dogiel (26); this I can corroborate. I have, however, never 

 been able to make out arborizations in the mucosa and only in 

 a few instances and this in methylen blue preparations from the 

 large intestine of a rabbit, have I been able to find nerve fibers 

 which seemed to me to end in the epithelium. In these prep- 

 arations, small varicose fibers, some of which were branched, 

 others not, could be traced for short distances between the 

 mouths of the crypts of Lieberkiihn. These were seen in the 

 same focus which brought to view the gland mouths and the 

 epithelial lining of the large intestines ; presumably, therefore, 

 were intra-epithelial. Whether some of the nerve fibers de- 

 scribed, and figured by Erik Miiller (27) and Berkley (28) from 

 Golgi preparations, as passing into the mucosa of the intestinal 

 canal, are the terminations of afferent fibers I am not prepared 

 to say ; it would seem to me not unreasonable to accept this 

 view. 



By way of summary it may be stated that the larger med- 

 ullated nerve fibers found in the hollow organs and gland ducts, 

 on reaching their termination branch repeatedly before losing 

 their medullary sheaths. This branching takes place largely 

 in the mucosa, to lesser extent external to the muscular coat 

 and in the muscular layer. The medullated fibers and their 

 branches run together in various ways to form the primary 

 plexuses. After losing their medullary sheaths, the fibers, now 



