A CONTRIBUTION ON THE NERVE TERMINATIONS 

 IN NEUROTENDINOUS END-ORGANS. 



By G. Carl Ruber, M.D., 



Junior Professor of Anatomy and Director of Histological Laboratory, University 

 of Michigan, 



and Lydia M. DeWitt, M.D., B.S., 



Assistant in Histology, and late Assistant Demonstrator .of Anatomy, University 

 of Michigan. 



With Platea XIII to XVIII. 



Some years ago, the writers undertook a series of research- 

 es on the innervation of muscular tissues in the belief that many 

 of the points still in dispute concerning the termination of the 

 nerve fibers and their relation to the elements of the tissue 

 might receive further elucidation, if, in such investigation, the 

 nerve fibers were stained differentially by means of a method or 

 methods which would admit of the making of thin sections of 

 the tissues to be studied. The method selected was the intra- 

 vitam methylen blue method, using ammonium picrate and am- 

 monium molybdate as fixatives. We have thus far presented 

 observations on the motor endings in voluntary muscle, heart 

 muscle and involuntary muscle, sensory ending in the neuro- 

 muscular spindles, sensory ending in the extrinsic eye muscles 

 of the rabbit, and sensory endings in the tendons of the extrin- 

 sic eye muscles of the cat. 



In the present contribution it is our aim to give the results 

 of extended observations on the ending of nerves in the neuro- 

 tendinous end-organs which, both from an anatomic and physi- 

 ologic standpoint, must be and are regarded as end-organs asso- 

 ciated functionally with muscular tissues. This investigation 

 embraces observations made on neuro-tendinous end-organs of 



