Benson A. Cohoe 187 
A comparison of the cellular structure of this gland with the gl. sub- 
maxillaris of the hedgehog (Hrinaceus ewropeus) discloses a similarity 
of structure which is at once both striking and suggestive. This gland 
in the hedgehog was first described by Kultschizky, 85, and later by 
Krause, 95. In the tubules of the gland are found granular and non- 
granular cells. With Biondi’s stain the granules assume an intensely 
red color, as does also the meshwork found within these cells. The 
granule-containing cell in the rabbit’s submaxillary react similarly with 
Biondi’s stain. The cells destitute of granules, which occur in the peri- 
pheral part of the tubule in the hedgehog’s gland are stained blue, while 
the clear, non-granular cells of the rabbit’s submaxillary are colored a 
violet-blue with this stain. The cytoplasm of these outer peripheral cells 
possesses ‘a well-marked network, within which granules are never found. 
The nucleus is often irregular and lies close to the basement membrane. 
Kultschizky described the granular cells as serous, and the cells lying 
outside of the latter and not containing granules as mucinoid. He was 
able to show that the two kinds of cells in this gland were arranged in 
regular groups and that the serous cells did not appear in the form of 
demilunes, as in the mixed salivary glands of other animals but occupied 
once in a while a great part of the gland lumen. 
Krause also called attention to the similarity existing between the 
submaxillary glands of the rabbit and hedgehog: “Es lag natztirlich 
sehr nahe der Submaxillaris des Kaninchens, in welchemn wie Nussbaum 
zuerst beschrieben hat, die Endstiicke der Ausfiihrungsginge zahlreich 
sich in Osmium sadure intensiv schwirzende Granula enthalten, welche 
der erwahnte Autor fiir Ferment Kornchen halt.” 
The relation of the two kinds of cells to each other in this gland of 
the hedgehog, while quite simple does not display the constancy nor 
regularity of position found in the corresponding gland of the rabbit, 
where the granule-containing cells always occupy a position intermediate 
between an intercalated duct and the group of clear or non-granular 
cells. In the hedgehog the tubule of granular cells branches simply, 
and its end piece is covered with these mucinoid cells. The latter are 
related in such a way to the former that mostly the middle of a small 
lobule contains only granular cells, which are surrounded by a garland 
of non-granular cells. This relationship Krause verified by means of 
Berlin blue injection. 
The similarity in the behavior of these cells of the two glands towards 
stains and in their microchemical reactions is very marked. In both 
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