224 Gastric Glands of Dog after Gastroenterostomy 
3. Changes in the parietal cells—The parietal cells, which Cade did 
not find in the glands next the anastomosis, appear in all my preparations, 
extending quite to the line of union. Up to stages two months after 
operation they are sometimes, though not always, less numerous than 
normally, in the two or three glands nearest the line of union. At 
stages of three months and later they appear in nearly or quite normal 
frequency in all the glands of the section, including those near the 
anastomosis. But while their number does not appear materially altered, 
some of them present changes after the operation, which may be attributed 
Losses 
In many glands there seems to be more variation than normally in 
the size of these cells. Four months after operation most of the parietal 
cells in glands near the anastomosis are smaller than in glands farther 
away. This I thought due possibly to pressure atrophy, since in this 
preparation the gastric mucosa was overlapped for a short distance by 
the duodenal. As in many other cellular structures affected by inflam- 
mation there is among the parietal cells a tendency to hyperplasia. Some 
few become quite large, possessing a diameter two or three times as great 
as that of ordinary parietal cells and provided with multiple nuclei, 
three appearing sometimes in my preparations. They are rich in granules 
taking the characteristic stain. They often contain vacuoles and fre- 
quently a very large number of spirilla (Fig. 1). They are found 
usually near the muscularis mucose and exist long after the operation, 
being found in preparations of ten months’ stages. Such large parietal 
cells are described by Bockelman, 02, in gastric ulcer in man attaining 
sometimes a diameter of thirty micra and containing two to four nuclei. 
The yellowish-green cells described above, which show an affinity for 
chromic acid salts, appear in somewhat larger numbers than in the 
normal mucosa, particularly during the week after operation, when 
nearly every gland section contains three or four cells of this type. 
Although most frequent in the gland bodies they are occasionally present 
in the necks. ‘They are often more irregular in outline than the neigh- 
boring parietal cells. Their nuclei are usually spherical and poor in 
chromatin. In the two or three glands struck by the knife which undergo 
degeneration they are not more frequent than in glands at some litlte 
distance from the incision. But from their irregular shape and their 
increased frequency in areas of subacute inflammation they would seem 
to be degenerative forms. 
In preparations six and a half months after operation I found in the 
parietal cells of gland necks close to the anastomosis a very distinct, 
cloudy area, near the nucleus (Fig. 4). Its outline was usually irregular 
