Basil C. H. Harvey 227 
ferment cells and appear as small islands in an area in which all the 
other cells contain mucus. This occurred in my preparations of three 
and four month stages. 
The exact extent of this change at the various stages after the opera- 
tion is shown in the following table: 
At 7 days it extends through 6 glands, with very few ferment cells in the 
next 40 glands. 
At 9 days it extends through §&8 glands. 
At 12 days it extends through 22 glands. 
At 15 days it extends through 55 glands. 
At 1 month it extends through 50 glands. 
At 2 months it extends through 36 glands. 
At 3 months it extends through 30 glands, except for two glands near the 
anastomosis, which contain three or four ferment cells in the ends of 
each. 
At 4 months it extends through 18 glands. 
At 5 months it extends through 4 glands. 
At 6% months it extends through 3 glands. (In one case.) 
At 6% months it extends through no glands. (In a second case.) 
At 10 months it extends through no glands. 
In the last two cases ferment cells were found in glands next to the 
line of union. 
This table shows the extent to which zymogen granules are entirely ab- 
sent from body chief cells. This extent can be easily determined, since 
there is no difficulty in detecting these granules in neutral gentian 
preparations even when only one or two are present in the cell. The 
intermediate zone immediately outside it, across which the number 
of granules gradually increases till the normal is attained, is wide 
enough to include ten to thirty glands to the radial section. 
Just as in the loss of the zymogenic function the prozymogen dis- 
appears before the zymogen granules, so in the reassumption by these 
cells of their zymogenic function, the prozymogen appears in the basal 
part of the cell before zymogen granules can be demonstrated in the 
free end, and in advance of those glands in whose cells zymogen granules 
appear are found glands whose cells, while containing in the free ends 
a substance showing an affinity for mucus staining dyes, contain in their 
attached ends a substance showing an affinity for toluidine blue and which 
resembles prozymogen. Such cells occasionally form the walls of small 
eysthike dilitations relatively remote from the line of union. 
There is, therefore, during the first two or three weeks after the 
operation, in the bodies of many glands immediately around the anasto- 
mosis a gradual replacement of the ferment cells by mucous cells, extend- 
