Ixviii Journal of Comparative Neurology. 



negative results, hence were never published. Within the last decade they 

 were resumed mof e systematically under the direction of Brown-Sequard 

 himself. Brown-Sequard's conclusions as summarized by himself may 

 be taken up in order. 



1st. Appearance of epilepsy in animals born of parents which had been 

 rendered epileptic by an injury to the spinal cord. 



2nd. Appearance of epilepsy also in animals born of parents which had 

 been rendered epileptic by section of the sciatic nerve. 



These points have been previously verified by others, and the sec- 

 ond was many times repeated by Mr. Romanes. The skin was removed 

 from the anaesthetic area behind the ear, the irritation of which caused 

 the fits, and it was found that no kind or degree of irritation supplied 

 to the subjacent tissue had any effect in producing a fit. 



3d. A change in the shape of the ear in animals born of parents in which 

 such a change was the effect of a division of the cervical sympathetic nerve. 



4th. Partial closure of the eyelids in animals born of parents in which 

 that state of the eyelids had been caused either by section of the cervical sym- 

 pathetic nerve, or by the removal of the superior cervical ganglion. 



The author performed few experiments and these with negative 



results. 



5th. Exophthalmia in animals born of parents in which an injury to the 

 restiform body had produced that protrusion of the eyeball. ... In these 

 animals, modified by heredity, the two eyes generally protruded. 



Brown-Sequard's results were in the main verified here, though the 

 author is not willing to base any final conclusions upon his experiments. 



6th. Haematoma and dry gangrene of the ears in animals born of parents in 

 which these ear-alterations had been caused by an injury to the restiform body. 



These results were corroborated. In the progeny the morbid pro- 

 cess never goes so far as in the parents which have been operated upon, 

 and it almost always affects the middle thirds of the ears. Two photo- 

 graphs illustrate this point. " It should be observed that not only is a 

 different /ar/ of the ear affected in the progeny, but also a very much 

 less quantity thereof. Naturally, therefore the hypothesis of heredity 

 seems less probable than that of mere coincidence on the one hand, or 

 of transmitted microbes on the other. But I hope to have fairly ex- 

 cluded both these alternative explanations. For, as regards merely ac- 

 cidental coincidence, I have never seen this very pecuhar morbid pro- 

 cess in the ears, or in any other parts, of guinea-pigs which have 

 neither themselves had their restiform bodies injured, nor been born of 

 parents thus mutilated. As regards the hypothesis of microbes, I have 

 tried to inoculate the corresponding parts of the ears of normal guinea- 



