Frederic T. Lewis and Fred W. Thyng 515 
the duodenum, two from the jejunum, and one from the umbilicus.’ The 
position of these structures accords with that of the early diverticula. 
The fact that an accessory pancreas with characteristic islands has been 
known to occur at the yolk stalk is in favor of Bremer’s interpretation of 
the nodular diverticulum. Opie” records the presence of two accessory 
pancreatic glands in a single individual. 
In describing the hepatic diverticulum of a 12-mm. pig it has been 
stated that “ sometimes a knob-like bud is found on its surface. Nearer 
the intestine these buds are more numerous. Some of them terminate 
in hepatic cylinders; others end blindly or are found as detached cysts 
in the liver.’ These structures are presumably the ones which 
Laguesse “ described in sheep embryos as pancreatic. He says: 
In the sheep I have found a whole series of small new buds arising late 
from the epithelium of the ductus choledechus and forming aS many accessory 
pancreatic glands .... In an embryo of 13 mm. none had appeared. None 
at 48 mm. At 65 mm., on the contrary, numerous little buds arose from the 
epithelial wall all along the duct but particularly near its outlet. Most of 
them appeared as tortuous tubes, some having branches. In an embryo of 
82 mm. a part of the tubular diverticula ended in simple or lobed secretory 
cavities, already presenting centro-acinal cells and chief cells containing re- 
fractive droplets like zymogen. I feel justified therefore in considering them 
to be true small pancreatic glands. 
We have not had an opportunity to examine such large embryos as 
Laguesse used, but in a sheep of 24.1 mm. (which shows several intes- 
tinal pockets) there are a few outpocketings along the bile and cystic 
ducts. One of these, somewhat elongated, is near the duct of the ventral 
pancreas. It is possible that the distal pockets may give rise to diverti- 
cula of the gall bladder, such as are found occasionally in the adult." 
That the others are pancreatic rather than aberrant hepatic structures 
remains to be established. 
° Wright, J. H. Aberrant pancreas in the region of the umbilicus. Journ. 
of the Boston Soc. of Med. Sci., 1901, Vol. 5, p. 497-498. 
© Opie, E. L. Anatomy of the pancreas. Johns Hopkins Hospital Bulletin, 
1903, Vol. 14, No. 150, p. 229-232. 
1 Lewis, F. T. The gross anatomy of a 12-mm. pig. Amer. Journ. of Anat., 
1903, Vol. 2, p. 217. 
2 Taguesse, E. Sur l’existence de nouveaux bourgeons pancréatiques acces- 
soires tardifs. Comptes rendus de la Soc. de Biol., Paris, 1895. Ser. 10, Vol. 
2, p. 602-603. 
1 Weltz, H. Uber Divertikei der Gallenblase. Inaug.-Diss., Kiel, 1894. 
20 pp. 
