516 Intestinal Diverticula in Embryos of the Pig, Rabbit, and Man 
It will be difficult to prove that any of the intestinal diverticula are 
pancreatic. Even the long unbranched diverticulum extending into the 
territory of the pancreas in the 20-mm. pig embryo might remain in that 
condition throughout life. Roth” describes a diverticulum of the duo- 
denum in the adult, situated 3 cm. from the outlet of the common bile 
duct. It is 1.5 em. deep, and consists of a mucosa and a thin submucosa ; 
the muscularis encircles it near its outlet. Its distal part is completely 
surrounded by pancreatic tissue. He reports four other cases of duodenal 
diverticula, in two of which the outpocketings extend into the pancreas. 
In one case the diverticulum had rounded subdivisions suggesting 
branches. Roth records two, other writers as many as four, diverticula in 
a single duodenum. 
Similar diverticula are well known to occur in any part of the intesti- 
nal canal, often in large numbers. Osler” reports three cases as follows: 
In one of the cases the jejunum presented 53 diverticula on the mesenteric 
border, all of hemispherical shape and attached by broad bases. They ranged 
in size from a cherry to a large apple .... There were not any in the 
ileum or colon. 
In the large intestine I have met with two instances of curious diverticula 
forming globular sacculi the size of large peas or cherries; very numerous 
in one case along the whole colon, in the other confined to the lower part. 
Such diverticula are commonly ascribed to constipation, marasmus, 
ete., rather than to developmental factors. They differ from the pockets 
which we have found in the intestine of the human embryo in their 
greater size and larger number, in their occurrence only along the mesen- 
teric attachment, and in their distribution which includes the large 
intestine. In older embryos than those examined it is possible that pockets 
may be found in the large intestine, especially since there is a tendency 
for them to develop down the intestinal tract, appearing first near the 
duodenum. It is possible, also, that they may become stretched out and 
obliterated along the convex surface of the intestinal loops, or may 
become directed toward the mesentery during the growth of the intestine, 
thus giving rise to a mesenteric distribution. If the diverticula of the 
embryo produce those of the adult, it is through pathological development 
and distension; their normal development is therefore to be sought. 
Roth, M. Ueber Divertikelbildung am Duodenum. Arch. f. path. Anat. 
u. Phys., 1872, Vol. 56, p. 197-201. 
1% Osler, W. Notes on intestinal diverticula. Annals of Anat. and Surg., 
1881, Vol. 4, No. 5. 
