Herrick, Pathology of Genei'al Pmalysis. 143 



feeblement were a slight speech disturbance, in the nature of a 

 blurring of the articulation, and awkwarkness in the gait that de- 

 noted slight incoordination. These facts are significant inas- 

 much as it will be shown that the most seriously affected corti- 

 cal areas are those in Broca's region and in adjacent parts, while 

 still more serious lesions are located in the coordinating centers 

 of the thalamus nnd mesencephalon. No sensory aura nor 

 other disturbances, nor any visual, auditory, or olfactory hallu- 

 cinations were detected. As it was not expected that a careful 

 pathological investigation would be possible, no dynometric or 

 aesthometric tests were made nor were systematic registrations 

 of temperature or urine analyses attempted. '^ 



NATURE OF THE DISEASE. 



Mendel says of the etiology of progressive paralysis : 

 "From the results there can remain no doubt that the es- 

 sential thing is interstitial inflamation. The cell-multiplica- 

 tion, development of spider cells, the increased excretion of 

 intercellular substance, these leave no doubt in this connection, 

 and at the acme of the disease, according to my observation, 

 the evidences of this inflamation are never absent." 



"In acute paralysis the nucleary proliferation and the de- 



*The following extract from a letter from Dr. Richardson re- 

 ceived too late to be inserted in the proper place will be of interest: 



"I have just learned a few facts in the history of J. S., whose case 

 you are investigating, which may be of interest in case it is not too late 

 to include them in the record. He was a man of more than usual 

 business activity and conducted a mercantile business in a small 

 town. He was always good hearted and indulgent and inclined for 

 years to the use of intoxicants in moderate amount when with his 

 friends. Through his indulgence to his friends his business became 

 complicated' during the years 1888 and 1889, and he was compelled 

 to make an assignment about the close of the latter year. In the 

 spring of 1890 he had an attack of La Grippe and after that never 

 seemed as well as before, and was somewhat despondent. He grew 

 worse that Fall and his disease began to change to a state of exalta- 

 tion. He became talkative and excitable and enthusiastic over busi- 

 ness, until finally, during the winter of 1890 and 1891, his actions 



