144 Journal of Comparative Neurology. 



velopment of spider cells is not great while they are replaced by 

 the phenomena of hyperaemia of the vessels or stasis through 

 the collection of blood corpuscles in the adventiva. In the very 

 aged the preceding processes of irritation are only here and 

 there to be noticed, or not at all ; the general atrophy extends 

 to include spider cells and granules." "The change in the 

 cell bodies is, so far as our methods show, a secondary process, 

 which in many cases can only be made out by microscopic ob- 

 servation, in a very limited extent, while in other cases, as 

 above shown, producing a very remarkable alteration." 



' ' Changes in the membranes are likewise, in the rule, sec- 

 ondary. . . . The pia as well as the dura, in most 

 cases, is implicated through the disturbances in the circulation 

 in the brain itself which react upon it, as well as through the 

 progressive diseased condition of the vessels. From all these 

 considerations I conclude that progressive paralysis is a diffuse 

 interstitial cortical encephalitis resulting in brain atrophy. 



"The beginning of the process is a transmigration of leuco- 

 cytes and it is accompanied by an increase of the connective 

 elements. The compression ot the capillaries and of the small 

 arteries through the accumulations in the adventitious sheath 

 disturbs the regularity of the nutrition of the nervous elements. 



became so unreasonable that he was adjudged insane and sent to the 

 asylum. He remained there until about May of 1891, during which 

 time he became more quiet and was finally taken home on a visit. 

 In June of '91 while at home he had a sudden epileptiform seizure 

 with hemiplegia on the right side, which, though not complete, lasted 

 for about three weeks. His speech was much worse after this than 

 before, and in August of the same year he had an attack of speech- 

 lessness lasting for a day or two, during which time he was entirely 

 unable to talk. Soon after this he was returned to the asylum where 

 he remained until his death and did not afterwards have any sudden 

 attack nor any symptons of local paralysis. The history during this 

 time we have heretofore narrated. There is no history of insanity in 

 the family. Uurmg the four years previous to his death he did not 

 drink any. In 1888 his only child became lost and the excitement 

 and worry in the search for him was a severe shock to him and his 

 friends were afraid at that time it would cause some mental trouble." 



