Herrick, Pathology of Genet al Paralysis. 149 



opalescence was noticed on the surface of the fresh brain and 

 some hemorrhagic patches along the sulci. The cerebellum 

 was superficially injected but section shows nothing abnormal in 

 its deeper portions. The membranes themselves were thickened 

 but there was no evidence of acute inflamation. The cortex 

 itself appeared nearly normal but the sulci were more conspic- 

 uous than would be expected from the age of the subject. The 

 atrophy was especially marked about the insula, fissure of Ro- 

 lando and the tip of the temporal lobe and not noticeable in the 

 occipital. A wax model made by the method of impregnation 

 of the right hemisphere with Japan wax brought out the atro- 

 phy more clearly as the shrinkage incident to the method was 

 more marked in the regions mentioned. The surface of the 

 brain was minutely pitted throughout its extent. The figure 

 sufficiently represents the configuration of the right hemisphere. 

 The weight of the entire brain was about 58 oz., and there 

 seemed to be an abnormal amount of ventricular fluid. 



THE MEMBRANES 



Circumstances have thus far prevented giving special atten- 

 tion to the meninges but, while somewhat thickened and ad- 

 herent and while the surface of the brain when removed had the 

 peculiar opalescent character so often described, the most notice- 

 able changes are connected with the vessels. In the sinuses 

 lying in the sulci great accumulation of leucocytes has taken 

 place and the leucocytes fill the considerable space about the 

 vessels and may be readily seen entering the brain and collecting 

 at various levels below the surface. These changes are simply 

 analogous to those which are taking place in the vessels within 

 the cortex and, like the latter, point to an inflammatory condi- 

 tion. 



In those regions in which the morbid changes are most 

 marked the blood vessels are also greatly affected. The first 

 characteristic of change is the increased number of white corpus- 

 cles and their transmigration into the surrounding tissue. There 

 can be no doubt that normally this transmigration is continually 

 taking place. The large pyramidal ganglion cells almost invari- 



