Herrick, Pathology of Gcnaal Paralysis. 151 



roglia (Fig. 9, Plate B). Opinion differs greatly as to the nature 

 of these bodies, but from the sections before us one might con- 

 clude that they are essentially amoeboid and their form depends 

 upon that of the interstices in which they may happen to lie. 



In the next succeding layer, that of small pyramids, the 

 changes are not such as to attract the eye but we soon notice 

 that a great number of the small pyramids have undergone more 

 or less pigmentary degeneration. While their processes and 

 form have altered little if any, small areas of degeneration are 

 present in the protoplasm. Sometimes these areas are appar- 

 ently but an extension of the normal pigmentation near the base 

 and adjacent to the nucleus, but it quite as often happens that 

 the area forms a rather sharply limited cyst in- other parts of the 

 cell. The pigmented areas refuse the stain and are recognized 

 by their own brownish yellow color. Fig. 5, Plate B. is a cell 

 from this region. In some cases the degenerated area causes 

 a bulbous protrusion of the cell, yet the nucleus is not at all 

 affected. In the third layer or region of medium pyramids the 

 conditions are not much different but before one reaches the layer 

 of large pyramids it appears that there has been a dispersion of 

 granules which fill the whole field. It is the region of the ram- 

 ification of small vessels. The larger radial vessels at this point 

 give evidence of important morbid changes; the walls at first 

 seem thickened but we soon see that the inner membrane or 

 intima seems normal, but the outer or adventitious layer is 

 gorged with leucocytes so that it occupies more space than the 

 lumen. One frequent result is that the cavity is more or less 

 occluded and the red corpuscles hence undergo degeneration. 

 Their coloring matter collects among the white corpuscles form- 

 ing haematoid masses. It seems improbable that this leaching is 

 due to the reagents — in fact, this is a well-recognized pathologi- 

 cal phenomenon. The smaller vessels are usually empty, as 

 though by the cutting off of the source of supply. Fig. 8, Plate 

 D, illustrates such a vessel as above described. See also Plate E. 

 It will be remembered that Flemming^ has shown that in the 



'Ueber Theilung und Kernforraen bei Leukocyten, etc. Areh. fUr tnikr. 

 Anaiom. xxxvii. p 249. 



