xvi Journal of Comparative Neurology. 



not able, as yet, to speak positively on this point, the patients having 

 been less than a month under treatment. In the other no influence 

 appeared to be produced." 



"Eight cases were of the grand ?ml variety. In two of these the 

 number of paroxysms has been reduced more than one-half, and 

 greatly mitigated in severity. In six other cases which were of long 

 duration I could perceive no curative effects." 



"In a case of general paresis no therapeutical influence was appar- 

 ent beyond that of arresting the delusions of grandeur for a few days. 

 In a case of hebephrenia, however, occurring in the person of a young 

 lady eighteen years of age, the effect has been most happy, the symp- 

 toms entirely disappearing in a little more than a month's treatment." 



"In several cases of nervous prostration, the result of long- 

 continued emotional disturbance, and in which there were great 

 mental irritability, dyspepsia, physical weakness, loss of appetite and 

 constipation, relief was rapidly afforded. In three other cases in 

 which the most notable symptoms was functional cardiac weakness, 

 the effect has been all that could have been desired. In these cases 

 it was employed in conjunction with ' cardine,' the extract of the 

 heart of the ox, made in the manner already described " 



These discoveries, associated with the respected names of H un- 

 mond and Brown Sequard, cannot fail to attract the attention of the 

 medical profession and, if found available, will open a new era in med- 

 icine. They promise also to throw fresh light upon the obscure prob- 

 lems of nutrition within the brain. If we recognize the fundamental 

 processes of neurosis as nutritive, anything which serves to determine 

 the nature and effects of the nutrition of the brain and nervous system 

 will be of great significance to psychology. The histology of nerve- 

 cells is advancing so rapidly that we may soon hope to know minutely 

 the nature of those changes which express themselves in the shrinkage 

 of the nuclei and destruction of the chromatin when a cell has been 

 subjected to long and exhausting stimulation or in cases of natural 

 exhaustion. 



Treatment of Insanity of Myxoedema bv Thyroid Grafts.^ 



Macpherson describes, in the Edinburg Medical Journal, 189", 

 No. 5, a case of myxoedema of three years' standing and character- 

 ized by melancholia and hallucinations. The tendon reflexes were 

 exaggerated, the extremities cold and oedematous. Menstruaiion 



1 Archives de Physiologic normale et pathologique, 4, 1992. 



