Ixxxii Journal of Comparative Neurology. 



justifies himself in speaking of " objective symptoms." Tlie patient 

 very generally experiences little or no alteration in general appearance 

 and his complaints are frequently met by incredulity. It becomes 

 important, therefore, to familiarize ourselves with those objective in- 

 dications, which may be called in evidence. Among the symptoms 

 discussed, conjestion of the head and face, concentric limitation of 

 the visual field and pupil reflexes, motor insufficiency manifesting 

 itself in incomplete closure of the eyes, imperfect convergence mo- 

 tions, fibrillary twitching and muscular twitching, hyphraesthesia, 

 modification of tendon and other reflexes, increased mechanical and 

 electrical irritability of nerves, disturbances of speech and writing, 

 circulatory changes, among them abnormal complications of the tem- 

 poral arteries of young patients, digestive disturbances, and of the 

 glands, kidney troubles of great variety. The paper, which contains 

 55 pages includes copious references to literature and cannot fail to 

 be useful if its materials are conservatively employed. 



The Early DGvelopmeiit of the Pineal Eye.> 



The author, came into possession of embryos of Iguana 

 iubenulata 7, 14, 18, 24 and 26 days old and others probably 30 to 

 40 days. The material were fixed in Kleinenberg's picrosulphuric 

 acid, stained in toto in borax carmine and sectioned in paraffin. 

 Models in wax were reconstructed from the sections. The results 

 thus obtained, like those of Strahl and Martin show conclusively, if 

 other proof were needed, that the view presented elsewhere in this 

 number by Mr. Sorensen, respecting the relations of plexus, epiphy- 

 sis and parietal organ is the correct one. The parietal vesicle is 

 clearly shown to be derived from an outgrowth of the epiphysis which 

 is formed quite independent of the paraphysis. The nerve is formed 

 independently of the epiphysis from a mass of cells just cephalad of 

 the epiphysis. It is shown that in Iguana, Lacerta and Anguis there 

 is no reason to doubt the origin of the parietal eye from the pineal 

 vesicle. 



' Klinckowstrom, a. de. Le primier development de Toeil pineal, 

 I'epiphyse et !e nerf parietal chez Iguana tuberculata. Anat. Anzeiger, VIII, 

 8-9, March, 1893. 



