cxxxvi Journal of Comparative Neurology. 



is required. We have also seen good preparations by the paraffin 

 method made by Dr. Burckhardt of Berlin but one would always fear 

 lest when exposed to unusual heat they would deform. 



Mr. Fish himself recommends a mixture of water 400 cc., 

 95 percent alcohol . . . . 400 cc, 



glycerin ...... 250 cc, 



zinc chlorid ..... 20 grams, and 



sodium chlorid . . . . ' . 20 grams. 



Afterwards the brain is dehydrated in alcohol and is passed into tur- 

 pentin, 3 parts, with castor oil, i part, for one or two weeks. After 

 drying on absorbent cotton it is varnished with bleached shellac. 



Another process substitutes for the last mentioned a mixture of 

 glycerin 100 cc. , castor oil, 100 cc, gum arabic or tragacanth, 50 

 grams. The specimen may be shellaced. Attention may be called 

 to a series of papers by Professor J. Frenzel of Berlin who has made 

 some very permanent and useful pliable preparations of entire bodies 

 of fish and reptiles.^ 



Myxoedema aud Cretinism Treated by Tliyroid Grafts and Extracts.^ 



The extended article mentioned gives a comprehensive view of 

 the efforts to apply the thyroid gland and its extracts to the treatment 

 of the obscure diseases of that gland. In February of 1890 Professor 

 Horsley suggested the possibility of grafting upon the human body 

 the thyroid of a sheep with the view of arresting the progress of the 

 disease. M. Lannelongue of Paris is thought to have been the first 

 to carry out the operation in 1890. 



The effects were prompt — too prompt perhaps to be attributed to 

 the slow changes of nutrition incident to a new generation of the se- 

 cretion and suggest that the improvement is due to the absorbtion by 

 the system of the secretion at the time in the gland. [Dr. George Mur- 

 ray, accordingly, prepared a fluid extract of the fresh thyroid of the 

 sheep with glycerine and injected subcutaneously. The result has in 

 almost every case proven satisfactory. Passing from the complex to 



^Verfahren zur Einbalsamirung von Fischen unci ahnlichen Objecten. 

 Naturw. Wochenschrift. VII, I2, 14, et. seq. 1892. Verfahren zur Herstellung 

 von zoolog. und anatomischen Preparaten mittelst der Glycerindurchtr5nkung, 

 Zool. Jahrbucher\, I, 1 886. 



^Beadles, C. F. The Treatment of Myxoedema and Cretinism, being a 

 Review of the Treatment of these Diseases with the thyroid gland, with a table 

 of 100 published cases. The Journal of Alental Science, XXXIX, 166, [N. S., 

 130-131.] 



