On opium. 



399 



acquired an evident bitter tafte, and a flight fmell ; which 

 was doubtlefs owing to my negle(5t of wjjkliig the mai's pre- 

 vioufly to the addition of the water. 



Experiment 28. 



Auguft 20th. At I 2 o'clock, I injeded a portion of this 

 aqueous folution (experiment 27.) between the ilcin and 

 mufcles of the right lower extremity, of a fine lively bul- 

 frog. At the fame time [ alfo injeded between the muf- 

 cles and the fkin of the left lower extremity, a mixture of 

 one part of alkohol, and two of water. He did not appear 

 fenfible of pain at the introdudion of either, but leaped 

 about in the receiver, in Avhich I confined him, with great 

 vigor. At 10 minutes after 12, he appeared equally vi- 

 gorous ; as he did at the expiration of 15. I now inject- 

 ed ibme more of the lame folution under the ficin of the right 

 extremity, but found no alteration evinced at the end of i o 

 minutes. I therefore introduced a third portion, at the 

 diftance of 25 minutes from the firft ; but without any al- 

 teration, excepting a flight convulfion, in drawing the leg 

 to the body, and which probably was occafioned by the 

 irritation of the inftrument ufed in injecting the folution. 

 Finding no effedt produced by the folution upon the muf- 

 cles of the extremities, i injeded a portion into the /o/A7/<r/6 

 at 30 minutes after 12. At 2,S minutes after 12, the right 

 leg was moved with confiderable difficulty ; and generally 

 remained in an extended pofition, unlefs firuck or other- 

 wife irritated ; when it was drawn forwards pretty forci- 

 bly. The frog could ufe it very well in the adlion of jump- 

 ing ; and he did not feem afte£led by what was taken into 

 the fi;omach, except that relpiration appeared to be increaf- 

 ed at the end of 10 minutes. 



A portion injeded into the recluni, produced no efFcd ; 

 and his legs had regained their perfcdt ufe. 



At 



