o N o P r u M. 405 



mon opium, B. (experiment 4.) beneath the (kin of the right 

 inferior extremity of a Hvely frog, at 15 minutes before i 

 o'clock. At I, he was quite hvely. By means of a probe, 

 I now detached the ligamentary union of the fkin at the 

 knee, and paffed a fecond portion of the fohition down to 

 the ankle joint. In 20 minutes he was as lively as ever. 

 1 now injefted a third portion and retained it fome time. A 

 prolcipjus <j/;/ occurred during the introdudlion of the folu- 

 tion by the fole exertion of the animal, as no force was em- 

 ployed. In 5 minutes his leg began to drag, and in i o 

 minutes he could not move it. The left was ufed with vi- 

 olence when irritated. 



At 20 minutes before 2, 1 injeded a portion into the fto- 

 mach, which almoft inftaijtly convulfed him, in a manne? 

 refemblingthecontradions produced by zinc and filver. His 

 irritability was fohighly increafed from the effects of the opi- 

 um, that the flighteft touch produced convulfions in all his 

 extremities. After fome minutes more had elapfed, afudden 

 noife or even blowing upon him, would produce them, and 

 they became more frequent by degrees. At 2 o'clock they 

 were lefs confiderable, and at i o minutes paft 2, he appeared 

 dead, as irritation produced no contradions. 



On opening the thorax, the heart beat 48 vigorous pul- 

 fations in a minute. The ftomach was filled with a flimy 

 m.afs, pofTefling the fmell of opium, and it appeared to have 

 contraded upon itfelf about the middle. The velTels on its 

 furface v/ere dirtended with blood. Contradions induced 

 by zinc and filver, were very inconfiJerable; being confin- 

 ed chiefly to the toes of the right leg, even when the filver 

 was placed in contad with the large iciatic nerves ; and in 

 the left leg, fimilar contradions extended no farther than 

 the foot. h.\. 3 o'clock ?ieitber would contrad. The auri- 

 cle was ftill pulfating 27 times in a minute. 



Having fhewn by the preceding experiments that there 

 exifts a great fimilarity between the effeds of the aqueous 



folutions 



