On opium. 



407 



For nearly 20 minutes he feemed to be dead. After 

 which a very flight touch convulfed him; and by this timo 

 the inflammation had extended to his toes. 



Some bufmefs carried me away at this period. I did not 

 return till nearly 3 o'clock, when 1 found the frog laying 

 as I left him; but the irritability of his fyftem was fo high- 

 ly increafed, that a very flight touch caufed ftrong convul- 

 five motions. I now placed him in a tumbler of water, and 

 at 20 minutes after 3, the merely making a noife, as in 

 the motion of a chair along the floor, and even only touch- 

 ing the glafs in which I had placed him, caufed fuch flirong 

 convulfions, as nearly to projedlhim from it. By degrees 

 this efi'ed: ceafed ; and by 4 o'clock he was quite dead. 



On opening the thorax the heart was beating 45 mode- 

 rate pulfations in a minute. The right leg exhibited ftrong- 

 €r marks of inflammation than the kfi-, as the vefl'els were 

 more turgid, and one or two confiderable effufions had 

 taken place into the fubftance of the mufcles, 



Experiment 27' 



Fifteen minutes before two o'clock, I Introduced a few 

 drops of the fpirituous tindlure, A. (experiment 7.) into the 

 ftomach of a fine lively bulfrog. A violent and inflianta- 

 ncous projection of the tongue fliewed a difpofition to vo- 

 mit it up. He jumped about under the receiver with great 

 vigor. In 1 o minutes he began to breathe more quickly, 

 and his jumps appeared more languid. When placed upon 

 the ground, he could not jump above twice or thrice his 

 length. About 3 o'clock he appeared to have recovered 

 confiderably from the effedls of the tincture. 



At ID minutes pafl: 3, 1 injeded a few drops below the 

 fkin of the right lower leg, which caufed confiderable pain. 

 A portion of it was loft, and a flight effufion of blood took 

 j^lace, which probably walhcd away another portion of the 



tindure 



