On opium. 



409 



mufcular fabric, became motionleis and relaxed. TIic eyes 

 clofed; refpiration ceafed; and a flight pulfation of the 

 heart, evmccd by the motion of the thorax, alone render- 

 ed it probable that any vitality remained. No contradions 

 of the extremities followed the application of a pointed in- 

 ftrument; but zinc and filver caufed ftrong conviilfive moti- 

 onsof the limbs. If the brain was touched with a filver probe, 

 and brought into contadt with the zinc on M'hich the fros: 

 was placed, ftrong contradlions of the body and limbs fuc- 

 cceded. When the probe was introduced to fome diftance 

 down the fpinal canal, the frog moved. At 25 minutes 

 paft one, he opened his eyes; and drew up foon after, his 

 extended lower extremities to his body. At times the muf- 

 cles of his upper limbs appeared ftrongly contraded, and 

 they generally remained in the fame pofition unlefs irri- 

 tated. 



At half paft one, he fuddenly became moft violently 

 convulfed; writhing his body and limbs, in every pofllble 

 direction; and he even threw himfelf with confiderable 

 force from the table on which he w^as placed, although at 

 leajlfix inches from its edge. During the period of thefe 

 violent convulfions he uttered a croaking noife. The con- 

 vulfions were induced by the flightcft noife, extending even 

 to the toes ; and they were more evident in proportion to the 

 Juddennefs of the caufe producing them. In 5 minutes this 

 effeft dirainidied confiderably, and his limbs when extend- 

 ed were flowly drawn up again to the body. 



At 20 minutes before 2, I left him feebly fupporting 

 himfelf upon his legs; and did not return till about 5 mi- 

 nutes before 3, when I found him under the receiver, and 

 lying upon his back, as if from a renewal of the preceding 

 convulfions. His eyes were open, and he moved fllghtly 

 when touched. A probe pafled down the fpine caufed his 

 extremities to move. In i o minutes from this time, very 

 little effed was produced by pafling the probe down the 

 3 H fpinal 



