340 VENOMS 
‘In the evening I saw my patient again. He was in bed, with a 
temperature of 372° C.; pulse 60; no malaise, no headache, no 
further vomiting ; he had taken a little soup, and a small quantity 
of alcoholic infusion of lime-tree flowers. He complained of his 
leg, which was swollen as high as the knee; the pain was greater 
in the calf than at the malleolus. I applied a damp bandage. 
The patient had a good night, and slept for several hours, but still 
had pain in the leg. On the following morning, July 24, I found 
him cheerful, with no fever, and hungry. Around the bite the 
cedema had become considerable, and had extended to an equal 
degree as high as the instep; the calf and thigh were swollen, but 
to a much less extent. J gave a second injection of 10 c.c. of anti- 
venomous serum in the cellular tissue of the abdominal wall. The 
day was good; indeed, the patient had no fever at any time; the 
spots at which the injections were made were but very slightly 
sensitive on pressure. In the evening the general condition of the 
patient was satisfactory ; he complained most of his calf. Thinking 
that a contraction was possible, due to his having hopped along 
quickly on one leg after the accident, I ordered him a bath. 
“On July 25, the second day after he was bitten, the only 
symptom still exhibited by the patient was a somewhat consider- 
able amount of cedema in the peri-malleolar region and lower third 
of the leg. This œdema was slowly and gradually absorbed on the 
following days. 
“ Remarks.—(1) At this season of the year viper-bites are both 
frequent and dangerous in this district of the Loir-et-Cher. A year 
never passes without several cases occurring, and it has very often 
happened that deaths have had to be recorded in spite of the most 
careful treatment. 
“ (2) The therapeutic effect of Calmette’s serum was rapid and 
efficacious ; the injections did not cause any pain or febrile reaction. 
“(3) The œdema resulting from the bite was a long time in being 
absorbed ; this, indeed, was the only remarkable symptom after the 
injection of the serum.” 
