HISTOLOGICAL CHANGES PRODUCED BY SNAKE VENOM 209 
ACTION OF SNAKE VENOM UPON THE HEART. 
Sometimes there are small hemorrhages in the periphery, but seldom in 
the substance. The muscular fibers present a slight fatty degeneration only 
in cases where extensive histological alterations are seen in the liver and 
kidneys. 
ACTION OF SNAKE VENOM UPON THE MUSCLES. 
The muscular fibers become necrotic within 30 minutes after the injec- 
tion. The venomized tissue is infused with a certain amount of albuminous 
mass rich in fibrine and the extravasated blood. After some hours there 
appears a number of polymorphic leucocytes between the degenerated mus- 
cular fascia. These leucocytes steadily increase in number and in one or 
two days reach the maximum. The muscular nuclei undergo alterations 
and become elongated or angular, giving an aspect of myoblast-sarcoblasts. 
In the protoplasma of myoblasts particles of destroyed muscle and fatty 
globules are frequently seen. 
In the accompanying plate both the longitudinal and cross-sections of 
venomized muscles are shown. Striated muscles are affected in a manner 
suggesting a partial dissolution of muscular substance. (Plate 33.) 
