258 VENOMOUS SNAKES AND THE PHENOMENA OF THEIR VENOMS 
With p = 1 and K = 0.048 gm., they found the value of g, shown under 
“q calc. J.” Figure 1o shows the results graphically. The tracing is the 
calculated values of ‘‘q,’’ while the circle shows the observed values. It will 
be noted, therefore, that the values derived from the experiments mentioned 
above can be expressed according to the simple formula 
dq 
re: Kq 
With rabbits and a constant dose of venom, 0.006 gm., they obtained the 
results shown in the last column of table 34. 
The neutralization of the hemolytic component of crotalus venom by its 
specific antitoxin gave the results (in grams) shown in table 35 and figure 11. 



TABLE 36. 
n q- q 
° 190 It 
Ts Ul etchsversyere 4 
2 5 4 
Bi Michelet estore T.5 
4 3-5 I 
6 a “a ievoraeaers 
8 int7 a een 
Io Eo Weveierieits'e 
3 
Te eee ON es Ce 
7 

\ So 
ase eee ee 
oO 2 a 6 8 10 Gone sae 3 4 
© Quinea-pigs weighing 450 gm. Fic. 13.— Guinea-pigs 
0. Guinea-pigs weighing370 gm. weighing 250,-: gm. 
Subcutaneous injec- 
Fic. 12.— Intraperitoneal injection. : 
tion. 
COBRA-VENOM ANTIVENIN. 
0.0005 gm. of this venom was 1 minimal lethal dose for guinea-pigs of 
about 500 gm. The antivenin used for this purpose was very weak and 
took about ro c.c. to neutralize 0.003 gm. of the venom. To 0.0028 gm. of 
the venom were added the amounts of antivenin indicated under n. The 
mixtures were, as usual, incubated for 2 hours at 36° C.; then the fractions of 
each mixture were injected intraperitoneally into guinea-pigs. Two series 
were undertaken with this antivenin, one with guinea-pigs of 370 and the 
other with those of 450 grams. The second series gave the estimate re- 
corded in the first column q of table 36. 
