144 ON THE EFFECT OF VARIOUS SUBSTANCES IN 



was lost, SO that the animal did not receive the full dose, yet it 

 died in 30 minutes. 



Chloride of zinc delays the action of the cobra poison, but 

 does not prevent it, as appears from Experiments X and XI, in 

 which a guinea-pig that had received 3 milligrammes of pure 

 cobra-poison (Experiment X) died in 45 minutes, whereas one 

 that had received a similar dose, previously mixed with chloride 

 of zinc, lived for about 3 hours (Experiment XI). 



Experiment X. 



March 1st, 1878. — 3 milligrammes of cobra-poison, dissolved 

 in 2 c.c. of distilled water, injected at 3.43 p.m. into a guinea- 

 pig's hip. Weight of guinea-pig, 20 oz. 



3.46 P.M. Twitching. 



3.50 „ Eestless twitching. 



3.53 „ The same. Irritable; squeals; quarrels with the 

 other guinea-pigs ; respiration jerky. 



4 P.M. The same. 



4.5 P.M. Drags the injected leg, which is nearly paralysed. 



4.15 P.M. Much the same. 



4.19 „ Paralysed, and crawls with difficulty; all hind 

 quarters invaded by poison's influence. 



4.21 P.M. Paralysis extending; struggles to rise; can only 

 move the head. Eeflex from eye diminished. 



4.25 P.M. Convulsive movements. 



4.28 „ Dead in 45 minutes. Heart continued to beat after 

 apparent death. 



Experiment XI. 



Red guinea-pig, weight 16 oz. At 3.46 p.m., March 1st, 

 3 milligrammes of cobra-poison, dissolved in 2 c.c. of distilled 

 water and mixed with 0-01067 chloride of zinc, were injected 

 subcutaneously. The poison and the chloride were mixed 

 5 minutes before injection. 



5.53 P.M. Guinea-pig restless; twitching; grunting; keeps 

 lickiug the puncture ; irritable with other guinea-pigs. 



4 P.M. Very restless. Puncture seems irritable ; leg partially 

 paralysed. 



