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PLATE II. CASE NUMBER 6.—THORAX AND SPINAL COLUMN OF 
MONKEY SHOWN ON PAGE 131, EXHIBITING DEFORMITIES. 
this early stage of the disease, it will be found that there are 
marked changes going on, especially in the bones. 
Considerable alteration in the form of the thorax will be found. 
The resistance of the bones is greatly diminished, and they break 
under a slight strain, so that fractures (particularly green stick 
fractures) and distortions are apt to be met with. Marked 
osseous changes may take place, apparently without constitutional 
symptoms. However, the patient soon loses its spirit and the 
general health fails. 
The skin is dry and the hair lustreless. There is beginning 
emaciation, the muscles becoming soft and flabby. The animal 
is generally subject to frequent attacks of indigestion, accom- 
panied by swelling and abdominal pain. No urinary manifesta- 
tions are present in this stage of the disease. 
Partial paralysis of the posterior extremities soon comes on, 
with atrophy of the muscles of the loin and limbs. The progress 
of the disease is now generally quite rapid, and the animal lies 
huddled up in a corner of its cage; if forced to move, rises 
languidly and with difficulty, and moves the limbs rigidly, as if 
they were without joints. Its locomotion is extremely cumber- 
