144 NEW YORK "ZOOLOGICAL SO CrEYs 
philia accompanies such disturbance, one would naturally expect 
a relative increase, at least in the eosinophilic cells. Though 
this does not appear to be the case in the instances observed by 
us, it is quite possible that in the earlier stages, when involvement 
of the bone marrow begins the conditions may be present and 
subsequently disappear. The gross appearances of the blood, in 
terminal cases, exhibit the usual characteristics of extreme 
anaemia and coagulation is oftentimes very much retarded. 
Muscles——No definite alteration, which can be looked upon as 
other than entirely secondary, has been found in the muscles. 
There are no changes in those of the paralyzed extremities, except 
a general wasting with fat absorption, though occasionally there 
is a relative over-deposition of adipose. The muscle cells be- 
come atrophied, but no nodes of disintegration or of nuclear pro- 
liferation have been seen and the atrophy seems to be entirely 
one of disuse, occasionally accompanied by a pressure-atrophy 
following over-deposit of fat. The muscles away from the im- 
mediately involved extremities show no changes, except such as 
are entirely dependent on the secondary conditions induced by 
the disease. No lesions of the smooth muscle distribution have 
been found. 
Osseous System.—Disease of the bony tissue appears to us to 
be the essential characteristic of the disorder and it is on these 
changes that we classify the disease as osteomalacia, identical in 
all its essential particulars with the condition so fully described 
as it occurs in man and the domestic animals. 
All the bones of the body, even those of the skull, eventually 
become involved. The changes are most obvious and deformity 
most prominent in those bones which may be looked upon as 
the supporting framework of the body; these are the bones of 
the lower extremities, particularly the femurs, the spinal column 
and those of the thoracic cage. The pelvis is relatively much 
less deformed than in man, probably because the weight of the 
body is less suspended on these bones in the monkeys, which 
ordinarily use the upper extremities for the purposes of locomo- 
tion, together with the lower. Very likely it is for this same 
reason that the thorax shows very early and much more pro- 
nounced deformities than is the cases in the human. 
One of the very earliest osseous deformities, consists in a bow- 
ing, usually a posterior kyphosis of the spinal column, most : 
marked in the dorsal region associated with a marked hypertrophy 
of the lumbar and sacral vertebrae. Lateral deviations are, in 
our experience, out of the ordinary. This-deformity is quite as + 
