150 NEWS YORK: Z© OLOGICAL SS O CIE: 
entirely localized to, the lungs and the adjacent lymph nodes, 
from which a general infection is very likely to arise. 
Spleen and Lymph Nodes.—Congestion and sometimes acute 
hyperaemia of these structures is present. As a rule, they are 
more or less enlarged, due to acute or chronic hyperplastic 
lymphadenitis. 
Ductless Glands.—TVhe thyroid gland shows no lesions, it is 
apparently neither increased nor diminished in size. The thymus 
body shows no variations from the normal. The adrenal glands 
frequently show congestion, with slight fatty degeneration of the 
cortical cells. 
Urinary Tract.—The kidney ordinarily shows more or less 
congestion with fatty and parenchymatous degeneration and occa- 
sionally slight interstitial nephritis. The bladder exhibits no 
alterations and we have never found it to contain calcareous 
deposit, as has been reported in occasional cases in man (Dock, 
American Journal of Medical Sciences, p. 499, 1895). We have 
not, as vet, studied the urine in these cases. 
Genital Glands——The disease has been found, in our cases, 
most frequent in males, even those presenting the osseous lesions 
supposed to be characteristic of “true osteomalacia,” and we are 
therefore unable to state as to the relationship between the ovaries 
and osteomalacia in the primates, though the bearing of the puer- 
peral state and the development of the disease in man seems to 
be well established. It is noteworthy that the primates chiefly 
affected rarely reproduce in captivity or show any marked sexual 
proclivities. In so far as we have investigated the disease, there 
seems to be no pathological changes present in the genital glands 
of either sex. 
Central Nervous System.—Changes in the central nervous sys- 
tem are constant in the well-developed stages of the disease and 
the symptoms arising from this involvement of the brain and 
spinal cord are among the most characteristic of the conditions, 
tending to overshadow the osseous alterations. Probably for this 
reason the condition has been commonly looked upon as a primary 
disease of the central nervous system and it was along these lines 
that we first undertook the study of the malady. In the light 
of more recent observation it appears to us that the osseous lesions 
precede those of the central nervous organs, which are probably 
secondary, though we must not forget that some observers still 
look upon the osteomalacia as a tropho-neurosis (Fehling; see 
Mallard. “Osteomalacie a forme nerveuse.” Bul. Soc. med. d. 
hop. de Lyon, 1903, 11). It does not appear at all strange that 
