NINGED ANNUAL REBORT, 161 
tion and a few of them are surrounded by an area in which the 
neuroglia is somewhat thickened. A few of the larger lymph 
spaces are surrounded by narrow zones in which a granular 
necrosis is present. The ganglion cells of the anterior horns show 
many evidences of degeneration, some of them are atrophic and 
more or less distorted, others show a simple deposition of coarse 
granules in their cytoplasm, while still others show only slight 
disintegration of the chromophilic plaques, no constant alteration 
is present, and doubtless at least a part of the changes are of post- 
mortem origin. Sections stained by the modified Marchi method 
show many degenerated fibers in the posterior columns, particu- 
larly in the column of Goll, in the anterior ground bundle and a 
few isolated degenerated fibers in the direct pyramidal tracts. 
Dorsal Cord.—Changes exactly similar to those described in 
the cervical cord are present, except that the column of Burdach 
is more involved in these levels and that relatively fewer degen- 
erated fibers are seen in the anterior pyramids. 
Lumbar and Sacral Cord.—General alterations like those of the 
upper segments are demonstrable, but degenerated fibers are rela- 
tively infrequent in the small posterior columns and are found 
only widely separated and in small number in the anterior col- 
umns. 
Cauda Equina.—The vessels of these nerve trunks show quite 
extensive hyaline degeneration and some of the trunks show an 
increase in the amount of endoneurium. Degenerated fibers are 
scattered throughout in small numbers, and are not confined to 
any particular trunks, they are not so numerous as in the trunks 
surrounding the lower dorsal segments, where many degenerated 
fibers were demonstrated. 
Bones.—Sections taken through the head of the greatly soft- 
ened femur show remarkable alterations. The layer of hyaline 
cartilage surrounding the bone is thickened and is found to be 
very highly cellular, much more so than normal except in the 
early stage of cartilage formation. As many as twelve cells may 
be found in a single lacuna and the arrangement into columns is 
disrupted. The blending into osseous tissue takes place in a very 
irregular line and at a generally deeper level than in the normal 
bone, and, even in the centers of the bony islands, areas of carti- 
laginous metaplasia are shown, while the borders of the bony 
spicules are blended with mucoid or cartilaginous tissue and occa- 
sional osteoclasts are scattered along them. In the greater part 
of the head of the bone, circular or oval areas of chondrification 
are found, the outer borders of which present radiating columns 
