NINE ANNUAL REPORT: 165 
tirely cartilaginous. Lumbar vertebrae enlarged, softened, and 
showing quite extensive anterior curvature. 
Blood Examination (specimen taken from ear, just before ani- 
mal was killed).—Haemoglobin 65 per cent (Dare). On draw- 
ing the blood it was found to be abnormally light in color and to 
flow very slowly, being of a somewhat gelatinous consistency like 
the blood in leuchaemia. It clotted rapidly, but the resulting clot 
was not so firm and compact as normal. 
The red cells are found to vary greatly in size, many microcytes 
and macrocytes being present. Poikilocytes are numerous, but 
no degenerated cells were found. A few normoblasts were found 
and a few megaloblasts. Blood plates are very numerous. Leu- 
cocytes are found to be relatively very frequent, a few of them 
are pigmented, and one very large mononuclear leucocyte was 
found. The differential leucocyte count shows: 
Polynuelearenentrophilesas +. 2 ana. 67-0) per cent: 
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The granules in the eosinophilic cells are notably smaller than 
in man, otherwise the cells do not appear to differ much from 
those found in the human. 
Bone Marrow (Smear).—Many abnormal cells are present. 
Giant cells, for the greater part polynuclear, with eosinophilic 
granulation are numerous. In some of them a typical karyokinesis 
is demonstrable while large megaloblasts showing almost any 
stage of karyokinesis are not infrequent. Dividing normoblasts 
are common. Notable is the large number of leucocytes with 
basophilic granulation, the granules being notably smaller than in 
man. Phagocytic cells, leucocytes and giant cells are very com- 
mon. Many of the erythrocytes present show very extreme de- 
generative alterations and free pigment granules are commonly 
found. 
MICROSCOPIC EXAMINATION. 
Cervical Cord.—The membranes of the cord show nothing 
abnormal. There is slight irritation of the perivascular and peri- 
cellular lymph spaces and some of them contain slight exudation 
of small round cells. The ganglion cells of the anterior horns 
show no alteration. Segments prepared by the Busch modifica- 
