168 NEW. YORIC ZOOLOGICAL, SOCIET= 
and extravasations of red cells into the splenic pulp are present, 
in greater or less degree, throughout the entire tissue. Exten- 
sive destruction of these cells is taking place and pigmentation 
resulting from this disintegration is general throughout. The 
Malpighian bodies in this species appear to be very small, but in 
places they have been encroached upon by a chronic perarteritis. 
Bone.—Shaft of Femur. The marrow is completely replaced 
by a dense mass of cells, among which mononuclears and epithe- 
liod cells appear most frequently. Polynuclear leucocytes, fibro- 
blasts single and multinucleated giant cells are also frequent. 
Normoblasts are found in but relatively small number and exten- 
sive destruction of blood cells appears to be taking place, as evi- 
denced by the presence of phagocytic endotheliod cells, the cyto- 
plasm of which is literally crammed with broken down red cells. 
The endostium is intact in most places, but in other areas is largely 
replaced by groups of osteoclasts which are evidently causing ab- 
sorption of the adjacent compact tissue. The Haversian canals 
of the compact bone are surrounded by broad zones of homo- 
geneous osteoid tissue which is limited from the compact bone 
by a fibrous band resembling endostium. Extravasation of red 
blood cells into this tissue is present in places, but in other areas 
it is strictly osteoid in character, though, as a rule, the Haversian 
vessels in the larger areas are surrounded by cellular tissue resem- 
bling that of the marrow. <A few of these spaces show an appar- 
ent cartilaginous formation resulting in replacement of the vessels 
and normal tissue. Not infrequently the blood vessels appear to 
be plugged by hyaline thrombi. 
CONCLUSION. 
We by no means consider this presentation of osteomalacia, as 
it occurs in the Primates, conclusive or final. The question is of 
the greatest possible importance to Zoological societies, and until 
some definite means of prevention can be devised, the subject can 
be looked upon as little more than opened. It is, therefore, our pur- 
pose in the future to study particularly the genesis of the disease 
and its treatment. For this reason it is first imperative that 
an especially careful study of the urine in the malady be made, 
particularly as to its increase in content of bone salts and as to 
the presence or absence of lactic acid in both urine and blood. We 
also propose to thoroughly investigate the condition as affected 
by the administration of the extracts of the ductless glands, nota- 
bly those of the thyroid and adrenal. 
