18 S. SAGUCHI 



The cells containing argentophile granules contain few or no 

 vacuoles corresponding to the dissolved out lipoid corpuscles; 

 from this fact and from their position in the periphery of the islet, 

 it is conceivable that these cells belong to the type which con- 

 tains specific granules. I am of the opinion that the argento- 

 phile granules are present in both a and h cells; in fact, some of 

 the nuclei of the cells containing argentophile granules are 

 spherical in shape and situated near one end of the cell. Unlike 

 these granules, the specific granules are stained only a faintly 

 brown color in the Cajal preparation. The e cell contains no 

 argentophile granules (figs. 48, 49, 50). 



The genesis of argentophile granules may easily be followed in 

 certain cells which are met with in the periphery of the islet or 

 between acinus cells. In shape these cells (figs. 45, 46) are simi- 

 lar to acinus cells and contain spherical nuclei in which numerous 

 argentophile granules of various sizes are visible. In some cases 

 these granules are found in the nucleus; in others, they are also 

 met with in the cell-body, while in the nucleus they are reduced in 

 number. From these observations, the inference that the ar- 

 gentophile granules produced within the nucleus pass into the 

 cytoplasm would appear justifiable. In my preceding work on 

 the acinus cells of the pancreas I have referred to the fact that 

 the nucleolini are stained a brown color by the Cajal method, 

 and that they often pass out of the nucleolus, even out of the 

 nucleus into the cytoplasm. In a similar manner the argento- 

 phile granules, I think, must be derived from the nucleolini, the 

 production being very active in this case. As regards the ulti- 

 mate fate of these granules, no definite conclusion can be reached 

 at present. It is, however, well within the bounds of possibility 

 that, after having undergone certain changes, they are eliminat- 

 ed from the cell-body or transformed into other cell constituents. 



Intracellular cord or network apparatus. A structure compara- 

 ble to the Golgi network is also found in islet cells. Although it 

 is manifested with ease by the Weigl method, it can also be seen 

 in preparations fixed in sublimate, sublimate-osmic-chromic acid, 

 or Rabl's mixture, and stained with iron-hematoxylin. The 

 structure presents four principal forms (figs. 34 to 40, 42 to 44) : 



