CYTO LOGICAL STUDIES OF LANGERHANS's ISLETS 41 



methods do not exhibit the same thing, but another network of a 

 different nature in a and h cells. However that may be, I am of 

 the opinion that the above two cell constituents, after having 

 undergone a certain chemical alteration, pass into the blood- 

 capillary. 



I have mentioned in my previous paper on the pancreas of the 

 frog that the acinus cell contains lipoid granules which are col- 

 lected in the basal portion, and that it is highly probable that 

 these pass into the blood-vessel and therefore may be looked 

 upon as internal secretion matter. From this it is conceivable 

 with some reason that the internal secretion of the pancreas is 

 derived from islet cells, as well as from acinus cells, though to a 

 less extent, a view held by Lepine ('05), Sirtori, ('07), and Grineff 

 ('11). But the same idea may also be formed from another 

 point of view; that is to say, from the fact that the cells which 

 are considered to yield internal secretions not only form larger 

 and smaller groups but are also scattered throughout the pancreas. 



Kanazawa, Japan 



January 5, 1920 



