author's abstract of this paper issued 

 by the bibliographic service, july 26 



CYTOLOGICAL STUDIES OF LANGERHANS'S ISLETS, 

 WITH SPECIAL REFERENCE TO THE PROBLEM OF 

 THEIR RELATION TO THE PANCREATIC ACINUS 

 TISSUE 



S. SAGUCHI 

 Anatomical Laboratory, Medical School, Kanazawa, Japan 



SIX PLATES (sixty-one FIGURES) AND FOUR TEXT FIGURES 



_ CONTENTS 



Introduction 1 



Minute structures of islet cells 5 



Historical 5 



Observations 7 



Specific granules : cell types : the nucleus 7 



Mitochondria 11 



Lipoid corpuscles 13 



The urano-argentophile apparatus 15 



Argentophile granules 17 



The intercellular cord- and net-apparatus 18 



Pigment granules 20 



Mitosis and amitosis 20 



The relation between the different types of islet cells 21 



Distribution of islet cells in the pancreas 24 



Relation between islet cells and acinus cells 28 



Postembryonic development of islet cells 28 



Ultimate fate of islet cells 34 



Formation and fate of the typical islet 35 



Functional significance of islet cells 38 



Bibliography 41 



INTRODUCTION 



As is well known, the pancreas of vertebrate animals is studded 

 with groups of peculiar cells which are characterized by a trans- 

 parent appearance due to the lack of zymogen granules, and 

 which accordingly can be distinguished with ease from the neigh- 

 boring acinus cells. Since Langerhans's ('69) discovery of these 



