94 JOSE F. NONIDEZ 



of acidophile rods in the intravascular leucocytes is by no means 

 a distinctive feature of these cells, for such rods may also develop 

 in extravascular granulocytes, although this is not so common. 



The transformation of a hemocytoblast into a polymorphonu- 

 clear cell may take place very early, even before the granules 

 begin to arise in the cytoplasm. The granules develop later and 

 attain a rapid increase in size (fig. 5, g). On the other hand, 

 nuclear constriction and deposition of granules may occur simul- 

 taneously, without a definite stage of granuloblast with round 

 nucleus. The final result is the same in every case, namely, the 

 production of a polymorphonuclear granulocyte. 



Although the hematopoietic capacity of the connective tissue 

 has considerably decreased in the gonads of mature birds, it is 

 possible to find isolated granulopoietic foci in both the testis and 

 the ovary. In the latter the production of granulocytes is a 

 general feature, though it varies a good deal in its intensity. 

 Small clusters of granule-laden leucocytes could be detected in 

 some parts of the testis in a Campine cock over one year old. 

 The occurrence of granular leucocytes in the adult testis has also 

 been reported by Goodale ('19) in an old hen-feathered silver- 

 spangled Hamburg. I have seen one of the slides of this bird, 

 and there can be no doubt as to the correctness of the interpre- 

 tation of such cells by the observer just mentioned. In most of 

 the cocks, however, scores of sections examined did not show a 

 single extravascular granulocyte. 



The granulocytes in the young and adult ovary occur both in 

 the stroma and in the theca externa of the follicles, usually 

 grouped in small granulopoietic foci. In some cases, however, 

 the production of granular leucocytes reaches such an intensity 

 as to constitute a true metaplasis of the connective tissue. One 

 of these cases has been represented in figure 18, drawn from a 

 slide of the ovary of a pullet, kindly sent to me by Dr. H. D. Good- 

 ale. The inspection of this figure shows that almost all the 

 stages represented in the hematopoietic foci of the embryo (figs. 

 7 and 15) are also present in the granulopoietic agglomerations 

 of the young ovary. This myeloid metaplasis is taking place 

 everywhere in the organ, in the stroma as well as in the theca 



