3o6 ESSAYS and OBSERVATIONS 



REMARKS. 



1. However different the appearances 

 in the above experiments may feem, at 

 firft f/ght, from the ordinary effecls of 

 opium upon man and quadrupeds, of ren- 

 dering the mufcles more inert ; yet they 

 will be found analogous to its effeds when 

 given in fo large a quantity as to kill ; of 

 which fee proof, in the learned work of 

 Dr Tralles on opium. S. i, Exp. lo. 

 p. ii8. 1 19. 



2. The animal is affe61ed in the fame 

 way, and to the fame degree, whether 

 the opium is applied inwardly or out- 

 wardly. 



3. The effeds are, however, more fpee- 

 dy, where the dofe is equal, when the 

 opium is applied inwardly, than when 

 applied outwardly ; as might have been 

 prefumed from the greater fenfibility and 

 delicacy of the inward organs. And in 

 us, from the greater proportional hard- 

 nefs and compa6lnefs of the ildn, the dif- 

 ference will probably be ftill more confi'^ 

 derable than in the frog, 



EX- 



