JI2 ESSAYS AND OBSERVATIONS 



(fv;o Trials), 



In the la ft place, I poured to drops' 

 under the fkin of the thigh only in one 

 frog, and the like quantity under the fkin 

 ot the leg only in another, without find- 

 ing that either of thefe members loft their 

 fe-nfe or motion, or that the reft of ihd 

 body was obfervably affeded, 



REMARKS. 



From the above experiments we learnv 

 i. That the nerves of the ikin are much; 

 more readily, and to a greater degree, af- 

 fedled by the opium applied to the inner" 

 fide of it, than to the outer fide of it thro' 

 the cuticula ; not that in this way of ap- 

 plying the opium, the nerves of the ilsin, 

 by the ftretching of the cellular mem- 

 brane, are tore ; for water poured in, in like 

 manner, does not deftroy the fenfibility 

 of the fkin. Nor perhaps can we fuppofe, 

 that the nerves of the muieles being af- 



feaedy 



