PHYSICAL AND LITERARY. 301 



Jjearned dlfTertatlon on opium'^. Into the 

 crural vein of an old dog forty two pounds 

 weight, he caufedbe injefted at three different 

 times, half an ounce of opiujn diffolved ,in 

 four ounces of water, filtrated, and of the 

 fame warmth with the blood of the animal. 

 The firfl time, about fifteen drams were, 

 thrown in, and very flowly. It had no obfer- 

 vable efted:. About an hour after, eight drams 

 more were injeded (lowly, and immediately 

 the dog was feized with ftrong convulfions : 

 the pulfe was frequent and fmall, and after 

 fome time he foamed at the mouth. But 

 there appearing no figns of immediate death, 

 after waiting an hour more, the lafl nine 

 drams were thrown in quickly j upon which 

 the pulfe became full and flow, and in a mi- 

 jiute or fo, the dog expired. 



From the preceeding experiments, we 

 may, I think, fairly draw the following con- 

 clufions. 



(a) Opium applied to the flomach, guts, 



cavity of the abdotjien and thorax and abdo- 



1 minal mufcles, foon lefTens, and after fome 



time intirely deflroys all feeling and power 



of 



^ Edinburgh Med. Effays, vol. v. p. i. art, xij. 



