PHYSICAL AND LITERARY. 315: 



not only a flop is put to the periftaltic mo- 

 tion of the guts, and to the propulfion of 

 the chyle*, but the fluids alfo fegin ta 

 ftagnate firft in the fmaller and afterwards 

 ii) the larger veflels -f ; while the heart be- 

 coming gradually Icfs fenfible of the Jiimu- 



lus 



. . ■ • • • ■ ~ ■■ .' f> 



* In a fmall dog, which Br. Kauu Boa-biiave o^ened^ 

 after having given him three grains of opium, he obfer'r 

 ved fcarce any periftaltic motion in the guts : the fto-. 

 mach was much diftended ; the pylorus was Ihut, and the 

 bread and milk, which the dog had taken with the opium 

 about ten hours before, was indigefted. There was no- 

 thing like chyle in the duodenum, nor any ladeal veflels 

 to be feen in the mefentery. The bladder of urine and 

 great guts were much filled, nor had the animal eva- 

 cuated either urine ox freces from the time he fwallowed 

 the opium. Impetum faciens Hippocrati di£lum, p. 402. & 403. 

 The learned Dr. Haller has alfo obferved, that opium 

 puts a flop to the periftaltic motion of the guts in frogs 

 and other animals, Afl. Getting, vol. ii. p. 154. 



f This my worthy Collegue Dr. y^ljlon obferved with a 

 inicrofcope in frogs into whofe ftomach he had conveyed 

 a few drops of a folution of opium in water. Vid. Me- 

 dical Eflays, vol. v. part 1. art. xii. And indeed the 

 great diftenfion of the heart and its auricle in frogs kill- 

 ed with opium (N'' 5. compared with N° 3. 6. & 10. above) 

 indicates a more than ordinary refiftance to the blood's 

 motion in the arteries, as well as a lefs degree of irrita- 

 bility in the heart. Further, is not the flow, full pulfe, 

 ^and dry parched mouth in thofe who have got an over- 



dofe 



