[ 5' ] 



had been feizcd with the meafles ; the eruption vras driven in by 

 the cold, and in ten days afterwards the pempliigus appeared. 

 The veficles (the largeft of whicli were fnipped) poured out, at 

 firft, a femipellucid ferum, but in the courfe of the difeafc dif- 

 charged a bloody ichor. In this cafe the tendency to putrefadion 

 was very flrong, but the patient recovered by the liberal admi- 

 . niftration of bark and wine. From this cafe I think we are 

 juftified in inferring that the nature of the fluid contained in 

 the veficles (howevef accurately it may be afcertained to be 

 a pure ferum in the beginning) may be fo altered in the courfe 

 of the difeafe, by its own fermentation, or by admixture with 

 other fluids of the body, from their velTels being broken down, 

 that it may at length ceafe to be a diagnoftic fymptom of this 

 diforder. 



But no author who has written on the fubjed of pemphigus 

 has mentioned an extraordinary peculiarity of this diforder, which 

 I have obferved in two inftances ; namely, that the veficles 

 have taken poffeflion of the internal parts of the body, and 

 proceeded in fucceffion (fome rifing while others decayed) from 

 the mouth downwards through the whole furface of tlie alimen;- 

 tary canal. 



The firft cafe in which I had the opportunity of obferving 

 this Angular and diftrefllng fymptom, was that of a woman 

 under the care of Dr. Gregory, at the infirmary of Edinburgh, 

 in 1783. This woman's menfes had been obftruded for two 

 years and an half. During that period fhe had been thrice before 

 attacked with the fame diforder, which had each time fupervened 

 upon a vomiting of blood. Her fkin was generally cool ; and her 



G 2 pulfe 



