DICTIDNAKY OK Till: ACTIVE PUINCiri.Er 



35 



Colour tests (negative) : 



Concentrated sulphuric acid \ 



„ „ ,, with sugar 



„ ,, „ „ nitric acid V<;oloiirless. 



., nitric acid 



hydrnchloric acid ' 



(7a) ISOCINCHONIDINE A. ; prepared lilje Isoquiniue ; crystalline plates ; 

 M.P. tX,'. 



Readily soluble in ether and chloroform. 



(7/<) APOCINCHONIDINEA.; formed like Apoquinine, but no methyl group 

 eliminated; crvstaliine, very bitter ; non-Huorescent. 



Precipitated by alkaline hydrates, and by ammonii, which gives an 

 amorphous pp., becoming crystalline. 



No pp. Rochelle salt. 



(7r) CINCHAMIDINE A. (Hydrocinchonidine, Forst) ; accompanies Cin- 

 chonidine, from which it maybe separated by fractional precipitation; 

 C„„H.,|;N'..0 or 0,,|H.j,NoO ; crystalline plates or needles ; M.P. 2 iO' ; laevo- 

 rotitory ; not fluorescent. 



Soluble in alcohol and chloroform ; with difficulty in ether. 



(7-/) HOMOCINCHONIDINE A. [regarded by Skraup as merely impure 

 Cinchonidiae, see (7)] ; CidHooN^.O (Hesse); accompanies Cinchonidine ; 

 crystalline prisms or plates. 



Soluble in alcohol and chloroform, scarcely in water. 



(S) ARICINE A. (Manzini's Chinovatine or Quinovatine ; Hesse's Cin- 

 chonidine V) ; exists to extent of 3 to 3j per cent, in China de Cusco vera 

 (false Calisaya bark), in which Moissan found no Quinine or Cinchoniue; 

 C2.,H„|iN20, + 2H.jO (Gerhardt, Hesse, Moi<san) ; i>omeric with Brucine; 

 crystallijies in long transparent needles; M.P. 18S°; Iscvo-rotatory 

 (-.')8-l 8° in alcohol, —!12'36'' in ether) ; alkaline, not bitter; salts mostly 

 crystalline (but the sulphate gelatinous from water, though crys. from 

 alcohol); acetate diffieullly sohible in water. 



Soluble in 100 part.s cold or 11 parts boiling alcohol, 33 parts ether ; 

 scarcely in ■'.vater. 



Precipitants : 



Alkaline hydrates. 



,, carbonate^. 

 Ammonia, somewhat .soluble in exces.s. 

 [Not tartrates of soda or potash.] 



Tannic acid. 



Picric acid. 



(rold chloride, yellow amorphous. 



Phospho-tungstic acid) , j i , • -nt\r\i-\ 



T J ' . ■■ 1 pp., cloud at 1 in .■)0,000. 



Jodo-potassic acid I'' ' 



Potassic icH^ide. 



Mercuric- potassic iodide, pp., cloud at 1 in 50,000. 



Colour tests (Wittstein believes the colours are due to impurity) : 



Concentrated sulphuric acid, dark green. 



„ nitric acid, intense green. 



Frcihde's reagent, blue, changing to green. 



(9) CUSCONINE A. (regarded by Wittstein as identical with preceding), 



CjHjiNjOj + '2H„0 ; crystalline plates or prisms, with metallic lustre; 



M.P. 110° (after loss of water) ; laevo-rotatory ( - 64-3 in alcohol) ; feebly 



alkaline; not bitter ; not fluorescent; salts mostly amorphous; sulphate 



gelatinous. 



Soluble in alcohol, acetone, and ether, very readily in chloroform, but 



scarcely in water. 



Precipitated by alkaline hydrates and ammonia ; scarcely soluble in 



excess. 



Other ]]recipitauts as un.der Aricine. 



Colour tests : 



Concentrated sulphuric acid, yellowish-green. 



Concentrated nitric acid colours the alkaloid dark green, the solution 



becoming yellowish-green. 



Frobde's solution, dark-blue •>«. olive green warm •>«. blue ou cooling. 



(11(0 CUSCONIDINE A. [possibly amorphous form of Cusconine (Hesse) ; 

 coinpar_^ also (8) and (0)] ; amorphous; dark brown. 



Reactions : 



Alkaline hydrates ) j- . i, a it 

 . ■ •' > du'ty yellow Hocculent pp. 



Ammonia ^ j j it 



Gold chloride I yellow amorphous pp., soluble with difficulty in 



Platinum chloride ) in water. 



To the solution in concentrated acetic acid : 



Sulphuric acid gives no pp. (distinction from Pariciiie). 



Nitric acid, cloud, changing to pp. of Cusconidine nitrate. 



Hydrochloric acid, cloud, disappearing on addition of water. 



(9i) CUSCAMIDINE A.; closely resembles the above, the oiilv difference 



(observed by O. Hesse, Ann. Chvn. Pharni., 200) beiug that Cuscamidine 



