192 



ALKALOIDS. 



alhiJokV of cinchona bark. The Latter found 1 part of cincho- 

 nine dissolve in 1,100 parts of spirit of that strength, but, as the 

 solution obtained in the separation of the alkaloids is not a 

 saturated one, he recommends the addition of 0*0002 gram 

 cinchonine for every cc. of such spirit used. He also found pure 

 ether (free from -water and alcohol) very suitable for the same 

 purpose, as it dissolves so little cinchonine that a correction is 

 scarcely necessary. The niixtiire of both alkaloids must be com- 

 pletely dried in the water-bath, and then very carefully poAvdered. 

 The separation of two alkaloids by means of ether may also l)e 

 accomplished by allowing the ethereal solution of both to evaporate 



ß 



Fig. s. 



gradually, and, if one should separate in crystals, remo^'ing the 

 other Ijy slow washing witli ether in the form of vapour. By this 

 method I succeeded with Marquis^ in seiiavAtmg delphiniite from 

 delphinoidine in perfectly colourless crystals. 



The flask «, containing the mixed alkaloids (Fig. S, A), was 

 inverted in the wide-mouthed bottle, h, into wliich about 10 cc. 

 of pure ether had Ijeen poured. Tlie ap})aratus was then allowed 

 to stand for several days at the ordinary temperature, during 

 which ether- va])Oi;r from b was continually condensing in a, and 

 dropi)ing back into h, saturated with delphinoidine. 



The apparatus figuied in 8 B, allows of the process being, to a 

 certain extent, regulated ; the funnel a, containing the flask, can 

 be raised or lowered at jdeasurc. 



^ Archiv f. cxper. Pathol, mid PharmaoL vii. 55, 1877. 



