CANCER 



143 



a,b, Mitotic segmentation into three segments. {After J. Arnold.) 

 c, Mitotic division into six segments. From a cancer of the breast. 

 {After J. Arnold.) 



" These still carry out the idea of segmentation in so far 

 that the geometric regularity of the forms is preserved and 

 the divisions show geometric similarity. This similarity 

 is not completely absent even in those asymmetric forms 

 which are occasionally developed (Hansemann). These 

 may be of great importance in certain circumstances, if two 

 intrinsically different daughter cells are produced. 



" In Fragmentation of the Nucleus (J. Arnold) the simple 

 geometric formation of the mitotic figures is altogether 

 absent. The whole ' habitus ' is different, but direct and 

 indirect fragmentation can still be differentiated. In 

 direct fragmentation the nucleus splits into numerous 

 subdivisions without any preliminary increase or rearrange- 

 ment of its chromatin. In indirect fragmentation there is, 

 on the other hand, an increase of the chromatin, which 

 assumes an irregular formation. It may be like a horse- 

 shoe, or ragged, or in the shape of a ring, a network, or 

 basket. Between the lobes and processes of the chromatic 

 figure are seen fine striated achromatic connecting lines. 

 During this process, in consequence of the irregular division 

 of the chromatin figures and the transformation of the 

 several parts into resting cell nuclei, large cells with many 

 nuclei, giant cells, are occasionally formed. An endogenous 



