251 



a-o-a m i no- 2p h e n y 1- o-h y d r o x y-6 (7)- c h 1 o ro chinoxaline 



is nut so readily soluble in alcohol as the foregoing. In order to 

 purify it, it is first crystallised several times fi'om alcohol and fînally 

 separated from the adheriug [i-isomer extracting with boiling ben- 

 zène in which it is less soluble. Yellowisli brown scales melting 

 at 2650. 



Analysis: 



0.1051 gr. gave 142 cw^ N (t=9-5o p=740 mm) 



found 15-7S7„ N 

 calcul, for 0^ H,o N3 Cl 15-51 „ „ 



This modification is generally less easily soluble in organic 

 solvants than tbe foregoing one. The solution in conc. bydrochloric 

 acid yields a red coloration with ether and on standing deposits 

 white needles. whicb are no doubt the corresponding hydrochloride. 



Conversion of 7. & [i-am i no-p h e ny 1 - h y droxy-chloro- 

 chinoxalines into the corresponding chloropbenazines 



This reaction is attained easily by boiling the chinoxalinede- 

 rivatives with glacial acetic acid and may be expressed by the 

 followins' formulae: 



— C = N 



C = N 

 NH„ OH 



Cl 



(Cl) 



= H, 0-f 



C = N — 

 C = N — 



NH 



Cl 



(Cl) 



The 7. isomere, melting at 265", yields x-D-chloro-indophen- 

 azine, which crystallises from alcohol in glistening scales, whereas 

 the ß isomere yields [i-D-chloroindophenazine. crystallising from 

 alcohol in vellowish needles. 



Br.^ Bromoindophenazine 



has been obtained in the following manner. Acetylbromoisatin was 

 dissolved in boiling acetic acid and aequimolecular quantities of 

 o-phenylenediamine hydrochloride and sodium acétate added. After 

 heating the mixture on a water l)ath for an hour, water has been 



