257 



III. 



Oll isatiu-oxiiiif etlins and derivatives. 



These substances may be obtained, as already pointed out, 

 by two différent methods. The first consists in heating the silver 

 sait of the osime with an alkylhaloide and the second in conden- 

 sing isatin \vith a alkyl-hydroxyhamine. 



B 6 n z y 1 e t h e r o f i s a t i n - o x i ni e. 



First niethod. The silver sait of isatin- oxime, wliich has 

 been obtained accordingto Baeyer's prescription, we heated with ben- 

 zylchloride in présence of alcohol on a water'__bath for several hours. 

 The silver chloride formed vras filtered off and the filtrate heated 

 with some charcoal. filtered again and left to cool. The ether crystal- 

 lised out in form of yellow needles; these were purified by several 

 recrystallisations from alcohol. 



The isatinoxime benzylether dissolves easily in alcohol, aceton, 

 benzène, ether. Caustic alkalis take it up with difficulty. The 

 alcoholie solution yields with ammoniac, silver nitrate a red pre- 

 cipitate, which is dissolved easily by an excess of ammonia. M. p. 

 168.5-169». 



Analysis: 

 0.1866 gr. gave 18.2 cm^ N (t = 20» p = 760 mm) 

 found calcul, for C15H12N., Og 



N U.190/0 11 -1370 



Second method. 



1.4 gr. isatin and the aequimolecular quantity of the hydro- 

 chloride of a benzyl hydroxylamine and sodium carbonate were hea- 

 ted in alcoholie solution in a sealed tube for three hours at 100". 

 The Contents of the tube were then treated with caustic soda in order 

 to remove the unaltered isatin and the part undissolved therein crys- 

 tallised twice from alcohol. The yield is almost quantitative. The 

 product obtained did not show any différences \yhen compared with 

 the one obtained by the first method. 



