797 



ride. The crystals obtained resembled in every respect acethaemin 

 and contained 62 94% C, 812%, 862% N and 03% OC 2 H 5 . 



The conversion of Moerners haemin into acethaemin may be 

 carried out just as easily. if not easier. using the corresponding bro- 

 niine Compound. 



Sixth préparation. 25 liters of an alcoholic solution of haemin. 

 prepared similarly as in the case of the first préparation, were trea- 

 ted with a 10% solution of hydrobromic aeid, in the following 

 manner: 



a) Y2 litre of the solution was treated at once with 15cm 3 of 

 the hydrobromic acid named, and left to stand to crystallize. The 

 crystals obtained varied in character, predominantly flat prisms 

 were found. A détermination of ethoxylgroups gave 2'25% OQ2 H 5 , 



b) the remaining 2 litres were heated to 50° and treated with 

 50cm 3 of hydrobromic acid of 10%- This time crystals were obtai- 

 ned in the shape of marbles, which contained 6 - 00%OC 2 H 5 . 



c) the mother liquor from b, containing still a considérable amo- 

 unt of colouring matter, was treated with hydrochloric acid. After 

 standing for some time, there were deposited crystals in the shape 

 of marbles and needles. which were dissolved in 400cm 3 of alcohol, 

 hydrochloric acid added, and the mixture kept at the boil for some 

 time. After cooling crystals were deposited in the shape of marbles, 

 although not well developed. They contained. according to a déter- 

 mination of ethoxylic groups — 8'9 u / OC 2 H ä . 



Seventh préparation. 2 gr. of the préparation VI b ; were dissol 

 ved in 100cm 3 of chloroform, two gramms of quinine added, and the 

 solution obtained poured into 500cm 3 , of glacial acetic acid, saturated 

 with potassium bromide. After cooling splendidly developed crystals 

 were formed, resembling in every particular those of ordinary 

 acethaemin; they contained however a small amount of chlorine, 

 a faet wbich explains sufficiently the somewhat high amount of 

 ßarbon found in thein. namely 59'66°/ C. They were also not quite 

 free from ethoxylic groups (found 0'89%), but there eannot 

 be any doubt that another recrystallisation, which could not be 

 carried out for want of a sufficient quantity of the substance, 

 would hâve lead to a product quite free from an admixture of 

 acethaemin - ethers. 



It is highly probable that acethaemin is the first coloured 

 décomposition product of haemoglobin, that this name eannot in 



