On í\)e l)Í6tcpQÍt)olcgic lesions of th)e bone^marrow 

 immunisation for ogglutinin proòuction 



by 

 Dr. C 1VIAOARINOÎS TORRES. 



I— Introduction and History. 



II— Subjects and methods of research. 



Ill— Hfstopathology of the bonc-raarrow. 



IV— Conclusions. 



(With plates 17-22.) 



The research work carried out du- 

 ring the last few years tends to indicate 

 lhe blood forming organs, bone-mairow, 

 spleen, and lymphatic glands, as the 

 seat of production of antibodies. 



Applications of X rays, benzol, tho- 

 rium X, etc., produce lesions in the 

 blood-forming organs of animals under- 

 going immunisation and modify the gra- 

 phics relating to the production of va- 

 rious antibodies. 



On the other hand the concentra- 

 tion of antibodies in the serum is con- 

 siderably increased by substances that 

 stimulate the blood-forming organs, such 

 as arsacetüi and salvarsan, independen- 



tly of a new injection of antigen. Frag- 

 ments of spleen and bone-marrow culti- 

 vated outside the body, are also able to 

 produce antibodies. Each of these organs 

 produces certain kinds of antibodies,- 

 thus the agglutinins are produced cliiefly 

 by the bone-marrow, which is not howe- 

 ver the hemolysln-producing organ. 



It is as yet impossible to ascertain 

 the function of the liver and ductless 

 glands in the production of antibodies, 

 as research work on the subject has 

 yielded such contractory results. It 

 seems likely that the ductless glands 

 (specially the thyroid and the parathy- 

 roid) do not actually produce antibodies 



