76 



of the ones which did not show conside- 

 rable daily oscillations (1) or an abnor- 

 mal number. 



The following observations of mine 



(1) These oscillations rarely exceed 3—4000 white 

 corpuscles per mms of blood. The following rabbit may 

 be taken as a normal rabbit with typical daily oscilla- 

 tions: 



Feb. 16 th 1921— White corpuscles=9.733 per mm3 

 (average of 3 determinations). 



Feb. 17 th 1921 -White corpuscles— 11.533 per ram3 

 (average). 



Feb. 18 th 1921— White corpuscles=^ 12.266 per ram3 

 (average). 



Feb. 19 th 1921— White corpuscIes==9:256 per mmJ 

 (average). 



demonstrate how sensitive bone-marrow 

 is to pathological conditions, showing 

 considerable morphologic modifications 

 which would introduce an important cau- 

 se of error into the interpretation of 

 experiments carried out under such con- 

 ditions. 



I adopted the following method. 



The rabbits were brought directly 

 from the rabbit-hutches of the Institute 

 to the laboratory and were killed as soon 

 as the number of white corpuscles hatf 

 been taken note of. 



In table II are indicated the results 

 obtained. 



Table II. 



Animal 



Rabbit 127 

 Rabbit 128 

 Rabbit 130 



Rabbit 271 800 grs. 



Rabbit 268 1.500 grs. 

 Rabbit 269 1.500 grs. 

 Rabbit 275 



Weight 



I Number of whi- 

 ¡ te corpuscles in 



II mm3 of blood. 



Rabbit 300 1.060 grs 



5.400 

 34.400 

 12.200 



(On June 3rd 



1920 at 2.55 



p. m.) 16.000 



(On July 17th 



1920 at 2.45 



p. m.) 16.000 



(On July 17th 



1920 at 3.20 



p. m.) 7.400 



(On Sep. 2rd 

 1920 at 2 p. m. 

 2.00 p. m. 10.600. 



Microscopic study of 

 bone-marrow. 



slight 



Congestion and 

 cedcnia of reticulum. 



Bone-marrow with nor- 

 mal aspect. 



Slight oedema of reticu- 

 lum; reduction in number of 

 the parenchyma-cells. 

 June 3rd 1920| Killed by Bone-manow sliowing 



«* o in ., .». ¡violent anaesthe- pronounced œdema of reli- 

 ât J.IU p. m. . ,^, . , , , , r r „ 



■SIS (Chloroform) culuni, atropliy of fat-cells 

 and foci of niultiiilicalion 

 of myeloblasts. 



July 17th 1920 

 at 3.30 p. ni. 



July 17th 1920 

 at 3.35 p. m. 



Do. 



Do. 



Do. Remai- 



Bone-marrow with nor- 

 mal appearance. 



Bone-marrow with nor- 

 mal appearance. 



Pronounced oedema of 



Aug. 7th 19201 



wh^n aaoni- ^^^ * ^^^ dayslreticulum, congestion, atro- 

 ¡in the laborsto-|phy of fat-cells, regressive 

 ^'"s* J ry getting rapi- changes in parenchyma, 



fdly thinner. abundance of pigment-cells 



(haemosiderin) are to be 

 •cen. 

 Sep. 3rd 1920 Killed by Bone-marrow with nor- 



¡violent anaesthe- mal aspect, 

 sis (Chloroform^. 



