CRYSTALLINE CONSTITUENTS OF OPIUM. 201 
Bromopapaverine itself is easily obtained from this substance, by digesting it 
with ammonia, and dissolving the product in boiling alcohol. It is deposited, on 
cooling, in minute white needles, insoluble in water, but readily soluble both in 
alcohol and ether. It dissolves in the acids and forms salts, the greater number 
of which are characterized by their sparing solubility. Its crystals were anhy- 
drous, and gave on analysis the subjoined results, — 
10-845 ... carbonic acid, and 
2°335 ... water. 
4-780 grains, dried at 212°, gave 
2:185  ... bromide of silver. 
These results correspond with the formula C,, H,, Br NO,, as is obvious from the 
calculation given below. 
{ 5°168 grains bromopapaverine gave 
Experiment. Calculation. 
_—e_e————* 
Carbon, - : 57-23 57°41 C,, 240 
Hydrogen, . ‘ ; 5:02 4-78 Heo 20 
Nitrogen, : c se 3°34 N 14 
Oxygen, : 4 “ 255 15°34 0, 64 
Bromine, . e ; 19°45 19-13 Br 80 
100-00 4:18 
Hydrobromate of Bromopapaverine—This salt is obtained, as already men- 
tioned, by the addition of bromine water to a solution of hydrochlorate of papa- 
verine. It varies somewhat in its appearance, according to the degree of concen- 
tration of the solution from which it is obtained. If concentrated, it is deposited 
with a more or less yellow colour, and is apt to form resinous lumps, particularly 
if the bromine water is added rapidly; but when the solutions are more dilute, 
it appears in the form of a perfectly white powder. It is well washed with water, 
dissolved in boiling spirit, and on cooling is deposited in a state of purity in the 
form of a crystalline powder, insoluble in water, and sparingly soluble in alcohol. 
When gently heated it melts, and is decomposed. When digested with potash 
or ammonia, it is decomposed, with separation of the base. Its crystals are anhy- 
drous, and gave the following results on analysis :— 
5-647 grains, dried at 212°, gave 
10°015 ... carbonic acid, and 
2°215 ... water. 
6-398 grains, dried at 212°, gave 
4883 --- bromide of silver. 
Experiment, Calculation. 
pee See 
Bete. RE AB ee 48-09 ©, 240 
Hydrogen, : c 5 . 4:35 4:20 H,, 21 
Nitrogen, 5 5 : a 2°80 N 14 
- Oxygen, 5 f . : ne 12:85 0, 64 
Bromine, 5 . ; “ 32:48 32-06 Br, 160 
100-00 499 
