mined with a “mercury solution,’ phosphoric acid with uranium 
solution and uric acid by precipitation and weighing as such. The 
results obtained were as follows: With moderate doses of potassium 
bromide (3°0-8°0 grams per day) urea was not affected, phosphoric 
acid was slightly increased, uric acid likewise, though much more 
decidedly; with larger doses of bromide (10°0-14:°0 grams per 
day, continued for 2-3 days) phosphoric acid was diminished in 
amount, but this Dr. Bill intimates could not be attributed to regular 
hypnotic action, since the other urinary constituents were likewise 
diminished, notably the urea. Both large and small doses of bro- 
mide increased the quantity of urine passed in the twenty-four hours. 
This Dr. Bill asserts was not due to the increased drinking of water, 
for no thirst, not even with the largest doses, was ever present. 
Dr. Schulze, experimenting on his own person, obtained results 
quite different from these. This investigator lived on a fixed diet of 
the following composition : 
154 Chittenden and Culbert 
Influence of Potassium 
220 grams fresh meat =17'13 grams N. 
50 grams air-dried wheat bread=0'92 grams N. 
30 grams cocoa powder =1'14 grams N. 
30 grams butter. 
30 grams sugar. 
5 grams salt. 
1500 grams water. 
9:19 grams N. 
The average amount of nitrogen excreted daily was about 11 grams. 
Taking this amount of food daily, with uniform habits of sleep, 
exercise, etc., Dr. Schulze states that he soon reached a point where 
the daily excretion of nitrogen, sulphur and phosphorus remained 
fairly constant. Potassium bromide was then taken three days, in 
divided doses of 10 grams each day. Diuretic action was very 
noticeable. Phosphorus was diminished, sulphur very much in- 
creased, and nitrogen (on two days) apparently slightly increased 
under the influence of the bromide. As, however, the increased 
excretion of sulphur was not accompanied with a corresponding 
increase in the excretion of nitrogen, Schultze considers that the 
increase in sulphur cannot be due to increased metabolism of sim- 
ple albuminous matter, and seeks to show that the potassium bro- 
mide must have decomposed, to a slight extent, some nitrogenous 
phosphorized principle or principles, such as lecithin (glycerine-phos- 
phoric acid) and nuclein, so abundant in the brain and nerve sub- 
stance in general. Schulze therefore concludes that under the influ- 
Ce el, v thee meres ae 
