and Ammonium Bromides on Metabolism. 155 
ence of potassium bromide there is probably a decided diminution of 
metabolic activity in the nervous system, accompanied by decreased 
nervous irritability. 
By determining the nitrogen of the feces, Schulze concluded that 
the bromide exercised no particular influence on the digestibility of 
the food. 
In our experiments great care was taken first, to insure body equi- 
librium and then to obtain sufficient data by analysis, to be sure of 
the requisite constancy in the composition of the daily excretions. 
The experiments were tried throughout on the person of one of us 
(W. L. C.), of good physique and vigorous constitution. The diet 
was weighed out each day with scrupulous care and was as follows: 
regi mest Pieeths iis eeprisl bi oe es yee 142°0 grams. 
IPO COSIs) SBS Ree om sek Es ee ee ae ee eee, Sic nl ene 
Wine abe RGa Gest saceiee 2 ee Ae ees Skary Ta 8 gre ad hoa 2560 ee 
(Opie Tae se Sees ia eS baa a es Tae ee DOsOmmne 
TEU IST es eae tar to aa hee sated i as dl Sahn ld ap SR green SO nies 
SUPEBee sense ee Se cies Sa Aerio Me OMten sen Phere) | ta 
ORI erase APSO fe OW Led BOS Ge eae beg SL ERE BOS OB 2 es mee Oxtw as 
WIN ce Benet ae oe hres Seen ty wee ete ee iy fe ae AE re ee O0;0me ce 
AWE G3 ot es ee aS ee ede See ee ee See ee ere 34D: ae 
This diet was commenced on the third day of April and continued 
for nine days before any attempt was made to ascertain the daily 
amounts of urea, etc., excreted. Then the urine was analyzed for 
nine successive days, after which doses of potassium bromide were 
taken. The above daily amount of food was divided into three por- 
tions and taken at the same time each day; at 7:30 a. m., 1p. m., 
and 6 p.m. Exercise was taken regularly and in stated amounts; 
consisting of a walk each morning before breakfast and exercise 
with dumbbells just before retiring at 11 p.m. Care was taken not 
to exercise so freely as to induce perspiration. Throughout the day 
routine duties allowed of regular habits. It was thus found possi- 
ble to keep even the minor conditions of the experiment constant 
throughout. The urine was collected from 7:30 a. m. of one day to 
7:30 a.m. of the next, and was at once analyzed. Urea was deter- 
mined by Pfliiger’s* modification of Liebig’s method, with a standard 
solution of mercuric nitrate. All the precautions so carefully worked 
out by Pfliiger; preparation of a mercuric nitrate solution of the 
proper specific gravity, a standard solution of sodium carbonate to 
